- Case Report
- A Case of Encephalopathy Presented with Motor Aphasia and Quadriplegia Following Intrathecal Methotrexate
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Seon Woo Lee, Eun Hye Park, Hyun-Sang Cho, Jae Kook Cha, Hae Ran Lee
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Clin Exp Pediatr. 2001;44(9):1066-1069. Published online September 15, 2001
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Intrathecal administration of methotrexate(IT-MTX) has constituted the standard approach to prophylaxis
and treatment of central nevous system(CNS) leukemia. We experienced a quadriplegia
and motor aphasia in a 14-year-old boy following repeated IT-MTX for the prophylaxis of
meningeal leukemia. He was diagnosed as ALL without CNS involvement and treated by CCG-
1882 protocol. IT-MTX was administered for CNS prophylaxis. The patient began complaining of
urinary incontinence,... |
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- Original Article
- Tumor Vaccine Effect by IL-16 Gene Transfer into Murine Neuroblastoma Model
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Hyun-Sang Cho, Chong Young Park
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Clin Exp Pediatr. 2001;44(1):68-74. Published online January 15, 2001
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Purpose : Interleukin(IL)-16 is a potent chemoattractant factor for CD4+ T cells, monocytes, and eosinophils. It up-regulates IL-2R on CD4+ T lymphocytes and regulates the function of antigen presenting cells. We used retrovirus-mediated gene transfer of the human IL-16 gene into the neuro-2a cells, which is the murine neuroblastoma cell lines, to investigate whether locally secreted IL-16 might generate anti-tumor... |
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- Case Report
- A Case of T-cell Acute Lymphoblastic Leukemia presented with Spontaneous Tumor Lysis Syndrome and Superior Vena Cava Syndrome
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Eun Jung Shim, Hyun-Sang Cho, Jae Kook Cha, Jae Kook Cha, Chong Young Park
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Clin Exp Pediatr. 2000;43(7):974-977. Published online July 15, 2000
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Acute spontaneous tumor lysis syndrome is a condition resulting from the rapid release of cellular
breakdown products into the circulation due to massive cytolysis occurring before start of treatment.
It occurs most often in Burkitt' s lymphoma and T-cell ALL, both of which have been well
described, following cytotoxic chemotherpy and other single agent administrations. However, only a
handful of spontaneous acute tumor lysis... |
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- A Case of Inappropriate ADH Secretion Secondary to Vinblastine Therapy
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Eun-Hye Park, Hyun-Sang Cho, Hae-Sook Yoo, Chuhl-Joo Lyu, Chang-Hyun Yang, Kir-Young Kim
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Clin Exp Pediatr. 1998;41(10):1430-1432. Published online October 15, 1998
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Inappropriate secretion of antidiuretic hormone(ADH) secondary to vincristine therapy has been reported frequently. But there has been five previous reports of vinblastine associated SIADH in the world and in 4 reports, bleomycin and cis-platinum were used along with vinblastine together. Because penetration of vinka alkaloids into CSF of humans is known to be poor, it has been suggested that lowering... |
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